This file contains the GWAS summary data corresponding to the individual SNPs used in the study “Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study”, published in JAMA Oncology (23 February online first publication).
The file contains information on:
outcome: name of the outcome trait tested
outcome_type: whether the outcome was a primary disease outcome, secondary disease outcome, or risk factor for non-communicable diseases
population: geographic origins of the source study
study, source of the individual SNP results as described in table 2, eTable 1 and eTable 2
subgroup: outcome subgroup
sd: standard deviation of the sample mean for the continuous trait tested
units: analysis scale for the risk factor tested
SNP: rsid for SNP
effect_allele: allele associated with longer telomeres
other_allele: allele associated with shorter telomeres
eaf_exposure: frequency of the effect allele in the telomere length GWAS
eaf_outcome: frequency of the effect allele in the outcome GWAS
chr.names: chromosome
chr.pos: chromosome base pair position (GRCh38)
gd: change in outcome trait per copy of the effect allele (log odds for binary outcomes: standard deviation units for continuous outcomes)
segd: standard error of gd
gp: standard deviation change in telomere length per copy of the effect allele
segp: standard error of gp
genes_ensembl: genes in close proximity to SNP as reported by ENSEMBL Biomart
group: whether disease or risk factor for non-communicable diseases