This file contains results of an MR analysis of the effect of BIRC5 gene expression on risk of cancer and cardiovascular disease in MR-Base, in response to the letter titled “Association between telomere length and risk of cancer and non-neoplastic diseases: is SURVIVIN the Ariadne's thread?”, published in JAMA Oncology. 

The results were derived from summary data made available by the following consortia and studies: GTEx, CARDIoGRAMplusC4D, C4D, ILCCO, PanScan1 and Capasso et al (PMID 23222812). Further details on the analysis can be found in the accompanying R script. 

The results file contains information on:

id.outcome: ID for the trait in available_outcomes()
id.exposure: ID for the exposure
outcome: name of the outcome
exposure: name of the exposure
method: Mendelian randomization method used
nsnp: number of SNPs in the analysis
b: log odds ratio per unit increase in BIRC5 gene expression
se: standard error of b
pval: p value for null hypothesis of no association
fdr: false discovery rate
author: first author of the outcome GWAS
category: outcome category 
consortium: name of GWAS consortium for the outcome
ncase: number of cases for the outcome
ncontrol: number of controls for the outcome
pmid: pubmed ID
population: population background for the outcome study 
sample_size: sample size
sex: outcome GWAS contains males or females or both
subcategory: subcategory for the outcome
trait: outcome trait
year: year outcome GWAS published
OR: Odds ratio for outcome trait per unit increase in BIRC5 gene expression
LCI: lower 95% confidence interval for odds ratio
UCI: upper 95% confidence interval for odds ratio