MR-base is a database and analytical platform for Mendelian randomization being developed by the MRC Integrative Epidemiology Unit at the University of Bristol.

You can either use the web application or our TwoSampleMR R package.

Data are also available through the MRC IEU OpenGWAS database.

Launch MR-Base webapp R package OpenGWAS database

Note - by clicking the "Launch MR-Base webapp" button you consent to the use of a cookie which enables us to ensure you have consented to the terms and conditions of data access. Information about how to control or delete cookies can be found at

MR-Base paper published

The MR-Base paper has now been published in eLife. See the publications page for details.

Telomeres paper published

Our paper reporting Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases has been published in Jama Oncology. See the publications page to access supporting data.

MR-Base Citation

Gibran Hemani, Jie Zheng, Kaitlin H Wade, Charles Laurin, Benjamin Elsworth, Stephen Burgess, Jack Bowden, Ryan Langdon, Vanessa Tan, James Yarmolinsky, Hashem A. $ The MR-Base platform supports systematic causal inference across the human phenome. eLife 2018. doi:

Software Citations


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